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How do drugs like Ozempic (semaglutide) cause weight loss? What happens when someone comes off of these drugs? In this episode, we discuss how these drugs (GLP-1 receptor agonists) target specific areas in the brain to suppress appetite and facilitate weight loss. We also discuss clinical trials data suggesting that these drugs and/or the weight loss that they facilitate may have cardioprotective effects. Lastly, we will also examine evidence regarding weight regain when coming off of these drugs and common side effects. Link to episode on neuroscience of appetite regulation: https://www.youtube.com/watch?v=i3RzV9vS_FA #healthspan, #semaglutide, #ozempic, #wegovy, #science, #weightloss Chapters: 00:00 - Intro 01:31 - What Does GLP-1 Do? 02:08 - GLP-1 Receptors in the Brain 02:52 - Activating the GLP-1 "Switch" (Receptors) 04:13 - Clinical Trials - Semaglutide for Weight Loss 05:29 - Semaglutide and Heart & Metabolic Health 05:54 - For How Long Does Semaglutide Work? 06:35 - Weight Regain After Stopping Semaglutide 08:24 - Side Effects of GLP-1 Receptor Agonists 09:37 - Take-Home Points 10:20 - Outro Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this podcast should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.

Get my FREE guide 3 Steps to Reverse Aging when you sign up for my weekly health picks 👉 https://bit.ly/IncreaseHealthspan View the Show Notes For This Episode: https://bit.ly/ep-832 Ozempic and other GLP-1 agonists like Wegovy have exploded as “miracle weight loss drugs.” But as the research unfolds, we’re quickly discovering that these drugs are not risk free and come with some very concerning side effects. In today’s episode of my series I’m calling Health Bites, I dive deep into the complexities of Ozempic. From nationwide shortages, high costs, the lack of insurance coverage, and severe, somewhat common, side effects, I explore the hurdles of Ozempic and question if it's truly a sustainable solution to our growing obesity crisis. This episode is brought to you by Mitopure and Cozy Earth. Support essential mitochondrial health and save 10% on Mitopure. Visit https://TimelineNutrition.com/Drhyman and use code DRHYMAN10. Right now, you can save 40% when you upgrade to Cozy Earth sheets. Just head over to https://CozyEarth.com and use code DRHYMAN. Here are more details from the episode (audio version / Apple Subscriber version): Current and potential uses for Ozempic and GLP-1 (6:42 / 4:01) Common side effects from Ozempic (8:48 / 6:07) Understanding the obesity and chronic disease crisis (9:33 / 6:52) Long-term risks associated with Ozempic (14:47 / 12:06) Combatting the idea that obesity is genetic (17:54 / 15:13) Can you be healthy at any size? (20:37 / 17:55) How traditional medicine misses the mark in addressing obesity (24:36 / 21:55) Clinical research findings of Ozempic use (31:44 / 29:03) Addressing the root cause of obesity and type 2 diabetes (35:34 / 32:53) Mentioned in this episode: Dr. Hyman’s Free Sleep Masterclass: https://drhyman.com/sleep Function Health: https://www.functionhealth.com/ The 10-day Detox Diet: https://www.amazon.com/Blood-Sugar-Solution-10-Day-Detox/dp/0316230022

The popular weight loss “miracle” drug, Ozempic, has been a topic of much debate and curiosity amongst Americans. With obesity hitting record heights and highly influential people, doctors, and celebrities singing its praises, it makes sense why people would be curious. Like most “quick fixes,” however, Ozempic is no magic bullet. While it holds great potential as a weight loss tool, there’s a knowledge gap that remains to be addressed about its proper usage and discontinuation among individuals. Today on The Dhru Purohit Podcast, we have a special compilation episode where Dhru speaks with several past podcast guests about the pros, cons, and best practices for taking Ozempic and other GLP-1 agonists. Dhru sits down with JJ Virgin to get her nuanced take on where these weight loss drugs might benefit those battling lifelong obesity and metabolic disorders. He speaks with Calley Means to get his insights on how these drugs are approved, the dirty tactics behind their marketing, and the agenda behind their streamlined FDA approval for obese teens. In a sneak peek of his upcoming episode, Dhru asks Dr. Gabrielle Lyon about what she’s seen in her clients taking Ozempic, the importance of resistance training and monitoring protein intake on these weight loss drugs, and potential side effects. Finally, Dhru highlights an interview with his wellness colleagues, Dr. Casey Means and Dr. Robert Lustig, on how to use Ozempic correctly and strategies to get off it safely. In this special compilation episode, Dhru dives into: -Why we’re talking about Ozempic and GLP-1 weight loss drugs -JJ Virgin’s nuanced thoughts on Ozempic -The importance of a healthy diet and lifestyle as an adjunct to Ozempic -Calley Mean’s criticism of Ozempic as a long-term solution to the obesity crisis -Financial corruption within the institutions funding weight loss drugs -Metabolic and comorbidity cost of Ozempic in teens -Dr. Gabrielle Lyon breaks down the best and worst practices around Ozempic -Side effects of Ozempic and other GLP-1 agonists -Dr. Casey Means and Dr. Robert Lustig on how to take GLP-1 agonists the right way -How to come off of them successfully -Evidence-based ways for sustainable weight loss in children Also mentioned in this episode: -The Top Weight Loss Do’s and Don'ts for Women 40+ with JJ Virgin (episode 407): https://podcasts.apple.com/us/podcast/dhru-purohit-podcast/id1381257272?i=1000619114815 -Whistleblower Exposes the Dirty Tactics that Coca-Cola Used to Rig the System and Keep Vulnerable Populations Unhealthy with Calley Means (episode 363): https://podcasts.apple.com/us/podcast/dhru-purohit-podcast/id1381257272?i=1000595414392 -How Does GLP 1 & Ozempic Affect Metabolic Health & Do They Work? | Dr. Rob Lustig & Dr. Casey Means: https://www.youtube.com/watch?v=AKNnxKAaONc -A Whole New Level - Levels’ podcast: https://podcasts.apple.com/us/podcast/levels-a-whole-new-level/id1563263076 -Well Beyond 40 - JJ Virgin’s podcast: https://podcasts.apple.com/us/podcast/well-beyond-40/id911502027 This episode is brought to you by: -Birch Living: https://birchliving.com/dhru -Pique Life: https://piquelife.com/dhru To get 20% off your Birch Living mattress, head over to https://birchliving.com/dhru today. For a limited time, Pique is offering my community 12% off their fasting tea bundle plus an exclusive gift! So head on over to https://piquelife.com/dhru to redeem this exclusive offer today!

Life Biosciences, a company co-founded by Dr. David Sinclair is developing the next-generation of Mitochondrial Uncoupling compounds. Dr. Jerry McLaughlin, CEO of Life Biosciences presents the goal and the progress of the project in this video. https://www.sciencedirect.com/science/article/pii/S0925443923002740?via%3Dihub https://pubmed.ncbi.nlm.nih.gov/32409697/ https://www.nature.com/articles/s41467-020-16298-2 https://pubmed.ncbi.nlm.nih.gov/34627389/ https://pubmed.ncbi.nlm.nih.gov/37900126/ David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming. Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives. Dr. Sinclair’s official lifespan podcast https://www.youtube.com/c/DavidSinclairPodcast. ______________________________________________________________________________________ Please note that the links below are affiliate links, so we receive a small commission when you purchase a product through the links. Thank you for your support! =*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*= ~*~ Discount Coupon Code: REVERSE 🌏ProHealth Longevity 15% OFF ~NEW~ Longevity Greens™ Powder https://prohealth.pxf.io/LongevityGreens Calcium AKG Longevity 500mg Caps https://prohealth.pxf.io/CaAKG ProHealth Trans-Resveratrol 500mg Caps https://prohealth.pxf.io/TransResveratrol Optimized Curcumin 500 mg https://prohealth.pxf.io/curcumin Quercetin/Bromelain Complex https://prohealth.pxf.io/quercetin Full Spectrum Apigenin https://prohealth.pxf.io/apigenin Green Tea EGCG Extreme™ https://prohealth.pxf.io/EGCG 🔬Renue By Science 10% OFF Liposomal Fisetin https://bit.ly/3PXYz5F Liposomal Spermidine 8mg 10% OFF https://bit.ly/44WNIgX Lipo Quercetin 150mg https://bit.ly/3K4mwVg 🧬 DoNotAge 10% OFF All Products http://tinyurl.com/wk688hav SIRT6 Activator http://tinyurl.com/mss7vrrn 🔶 Nuchido Time+ Supplement FIRST ORDER 20% OFF Code : REVERSEAGING20 Restore Our Cells Ability To Make NAD Like When We Were Young ~ https://www.nuchido.com/REVERSEAGING 🍀 iHerb New Customer 20% OFF code: NEW20, existed customer 5% off Discount Link https://iherb.co/sUBAZcqw =*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*= --------------------------------------------------------------------------------------------------------------------------------------------------- DISCLAIMER: The information and opinions expressed in this video are for informational purposes only and are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please consult with your doctor or other qualified health provider before start taking any supplements. #DavidSinclair #mitochondria #uncoupling #sauna #epigenetic #reprogramming #longevity #mitochondria #brownfat #Fasting #longevity #SIRT1 #d3k2 #spermidine #berberine #reverseaging #supplement #oskgenes #slowaging #resveratrol #stayyoung #EGCG #VitaminB12 #MethylDonors #TMG #NadBooster #Exercise #NAD #BeingHungry #Mitochondria #ALA #Metformin #CoQ10 #Carnitine #Antioxidant #LookYounger #Resveratrol #Quercetin #Fisetin #senolytics #OliveOil #Sirtuin #HIIT #aging #Lifespan #NR #Metformin #Berberine #ReverseAging #Epigenetic #OleicAcid #NAD #Sirtuins #Fasting #Longevity #RestoreYouth #Reprogramming #DavidSinclair #Healthspan #Younger #antiaging #DrSinclair #NAD #longevity #Bioscience #Epigenome #prohealth #donotage #renuebyscience #nuchido

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