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Statins reduce risk of cardiovascular disease but also come with mild to severe side effects. Nowadays, there are several alternatives — each with their own list of pros and cons. Here's what Peter covers: (00:32) How statins work to lower cholesterol (01:12) The percentage of people who develop muscle aches while taking a statin—and how to reverse it (01:32) The percentage of people who develop insulin resistance while taking a statin (02:48) A subset of people taking statins experience increased transaminases (03:18) Do statins impair mitochondrial function? (10:01) Why many people supplement with ubiquinol while taking a statin (11:11) Do statins increase neurodegenerative disease risk? (14:57) The only 4 statins Peter Attia prescribes (15:32) Ties between desmosterol levels & dementia risk while taking a statin (19:59) Statin alternative #1 - PCSK9 Inhibitors (21:37) Statin alternative #2 - Ezetimibe (25:03) Statin alternative #3 - Bempedoic acid Download the FREE 9-page Cognitive Enhancement Blueprint: https://bdnfprotocols.com/ Watch the full episode: https://www.youtube.com/watch?v=Dyid7vWO0zI

Is metformin a magic pill for longevity? Peter Attia's self experimentation with this glucose lowering drug is all about following the latest research.

Get the 5 Tactics in My Longevity Toolkit and my weekly newsletter here (free): https://bit.ly/3s04Owp Watch the full episode: https://youtu.be/em5xwtivnkg Become a member to receive exclusive content: https://bit.ly/3O0pEnY This clip is from 276 ‒ Special episode: Peter on longevity, supplements, protein, fasting, apoB, statins, & more. In this special episode of The Drive, Peter discusses a variety of topics, breaking away from the typical deep-dive format to explore a wide range of common questions submitted by listeners. In this clip, we discuss: - What products Peter takes - Why Peter’s lowered his vitamin B-6 intake - Peter’s daily magnesium target - What Peter takes in the morning versus at night - And more -------- About: The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more. Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan. Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies. For a full list of our registered and unregistered trademarks, trade names, and service marks, please review our Terms of Use: https://peterattiamd.com/terms-of-use/

How do drugs like Ozempic (semaglutide) cause weight loss? What happens when someone comes off of these drugs? In this episode, we discuss how these drugs (GLP-1 receptor agonists) target specific areas in the brain to suppress appetite and facilitate weight loss. We also discuss clinical trials data suggesting that these drugs and/or the weight loss that they facilitate may have cardioprotective effects. Lastly, we will also examine evidence regarding weight regain when coming off of these drugs and common side effects. Link to episode on neuroscience of appetite regulation: https://www.youtube.com/watch?v=i3RzV9vS_FA #healthspan, #semaglutide, #ozempic, #wegovy, #science, #weightloss Chapters: 00:00 - Intro 01:31 - What Does GLP-1 Do? 02:08 - GLP-1 Receptors in the Brain 02:52 - Activating the GLP-1 "Switch" (Receptors) 04:13 - Clinical Trials - Semaglutide for Weight Loss 05:29 - Semaglutide and Heart & Metabolic Health 05:54 - For How Long Does Semaglutide Work? 06:35 - Weight Regain After Stopping Semaglutide 08:24 - Side Effects of GLP-1 Receptor Agonists 09:37 - Take-Home Points 10:20 - Outro Social & Website: Instagram - https://www.instagram.com/sterlingmdphd Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/ The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this podcast should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.