REVERSE AGING To Prevent &Treat Diseases 2023 Nov Update | Dr David Sinclair

Researchers are making significant progress in understanding and potentially reversing the aging process, with a focus on using epigenetic regulators and cellular mechanisms to prevent and treat age-related diseases in humans

𝑸𝙪𝒆𝙨𝒕𝙞𝒐𝙣𝒔 𝒕𝙤 𝙞𝒏𝙨𝒑𝙞𝒓𝙚 𝙙𝒊𝙨𝒄𝙪𝒔𝙨𝒊𝙤𝒏

• What is the focus of the video?

  —The video focuses on understanding and potentially reversing the aging process using epigenetic regulators and cellular mechanisms to prevent and treat age-related diseases in humans.

• What is the significance of the Sur 442 mutation?

  —The Sur 442 mutation initially made no sense but eventually became significant in the study of aging and disease prevention.

• What was overlooked in the 2000s in the field of epigenetics?

  —The role of sirtuins in regulating proteins and impacting chromatin compaction was overlooked in the 2000s.

• What is the impact of epigenetic changes on aging?

  —Epigenetic changes, DNA damage, and cell stress can accelerate aging, and aging is a result of cells responding to damage, including DNA breaks.

• What are the potential benefits of reversing aging in humans?

  —Reversing aging in humans could prevent and treat diseases, with a focus on brain health, and potentially restore vision and function in various tissues.

Key insights

• 🧬 NAD boosters have been in humans for 3 years and are showing efficacy in lowering cholesterol, blood pressure, and improving endurance, with similar results to those seen in mice.
• 🧬 There is a backup of youthful information encoded somewhere in every cell, and there are ways to access and reset this information to reverse aging.
• 🧬 Changes to the epigenome may have a significant impact on aging and age-related diseases.
• 🧠 The search for the backup copy of youthful epigenetic information was almost given up on, but persistence paid off.
• 🔬 Reversing the age of nerve cells in the eye led to unprecedented nerve regeneration, suggesting potential for treating age-related diseases.
• 🧬 The use of adno Associated virus to deliver yamanaka factors shows potential for aging reversal in humans.
• 🧬 The figure shows that there truly is a backup copy of youthful information in Vivo, with the cell knowing which gene to change the expression and in what direction.
• 👁️ Treatment with yamanaka factors can restore the function of a monkey's eye by reversing the age of those animals.

#Health #Wellness #Aging #Longevity #Healthspan

𝐂𝐥𝐢𝐩𝐬

• 00:00 🔬 New data on NAD boosters showing efficacy in humans, epigenetics of longevity, and the discovery of the Sur 442 mutation in yeast cells.
  • New data on NAD boosters showing efficacy in humans, with published papers and similar results to mice, but the speaker will not discuss it further.
  • The speaker discusses the topic of epigenetics of longevity and the work done in yeast cells in the 1990s.
  • Brian initiated the project and discovered the Sur 442 mutation, leading to the seruan field, which initially made no sense but eventually became significant in the study of aging and disease prevention.
• 03:25 🔬 Aging is controlled by epigenetic regulators like sirtuins, which can reset cells to access youthful information and prevent diseases.
  • Silent information regulator number four is linked to aging and controlling gene expression, teaching us about our own aging and the importance of epigenetic regulators.
  • The field of epigenetics, specifically the role of sirtuins, was overlooked in the 2000s, despite their ability to regulate proteins and impact chromatin compaction.
  • Aging is not just a breakdown of our bodies, but rather there is encoded information in every cell that keeps the cell young, and there are genetic and potentially cheaper ways to reset a cell epigenetically and access this youthful information.
• 07:05 🔬 Genomic instability can lead to age-related issues in mammals, but cells have a mechanism to repair damaged DNA, which works well for young organisms, leading to testing a theory on aging in mice.
  • Genomic instability in yeast cells can lead to distraction of certain proteins from their main job of controlling gene expression, potentially leading to age-related sterility and gene expression issues in mammals.
  • Cells have a mechanism to repair damaged DNA through epigenetic factors, but this system works well for young cells and organisms, not so well for old ones.
  • The speaker discusses testing a theory on aging by building a mouse with inducible changes to the epigenome.
• 10:33 🔬 Treatment with a cutting enzyme repairs DNA contacts and changes in DNA arrangement in cells may be a major driving force of disease in mammals.
  • Mimicking genomic instability by cutting chromosomes in mammalian cells and mice does not cause an accumulation of mutations or cell death, but rather a mild DNA damage response that can distract cells for 3 weeks.
  • Changes to the epigenome can have an impact on aging and treating mice with a system resulted in similar epigenetic changes to normal aging.
  • Treatment with the cutting enzyme repairs DNA contacts and changes in DNA arrangement in cells may be a major driving force of disease in mammals.
• 13:16 🔬 Researchers collaborated to reverse aging in tissues, using animal testing to find success in using three yonara factors to prevent and treat diseases.
  • Collaborating with 64 scientists from 15 labs worldwide, the research focused on reversing aging in various tissues such as bones, eyes, skin, and muscle.
  • Animal testing was done to see if aging could be reversed by finding the backup copy of youthful epigenetic information, with the student almost giving up before finding success.
  • The discovery of using three yonara factors and leaving off Mick to reverse aging in cells without erasing their identity was a breakthrough in preventing and treating diseases.
• 16:03 🔬 Reversing cell aging can protect against nerve damage and promote vision improvement, suggesting potential for treating diseases like glaucoma.
  • The model of nerve damage in the eye showed that reversing the age of cells can protect them from dying and promote nerve growth, suggesting potential for treating diseases like glaucoma.
  • Mice were able to improve their vision through a study on aging using adno Associated virus to deliver three of the yamanaka factors.
  • Mice treated with DNA methylation showed restored vision and younger methylation age, indicating a backup copy of youthful information in cells.
  • Epigenetic changes, DNA damage, and cell stress can accelerate aging, and aging is a result of cells responding to damage, including DNA breaks.
• 20:05 🔬 Human studies on reversing aging to prevent and treat diseases will be initiated soon, with a focus on brain health, and there are advances in reprogramming cells using chemicals to reverse aging.
  • Treatment of non-human primates with yamanaka factors improved their vision and restored the function of the monkeys' eyes by reversing their age.
  • Human studies on reversing aging to prevent and treat diseases will be initiated soon, with a focus on brain health.
  • Organoids can be aged to 70 within a week, Alzheimer's disease can be reversed in mice, and there are advances in reprogramming cells using chemicals to reverse aging.
• 23:23 🔬 Cells have a memory of epigenetic usefulness that can be tapped into, with many people helping to make this possible.

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