Medical Interventions (TRT, HGH, Stem Cells, etc.) For Longevity | Lifespan w Dr. David Sinclair #5

The video discusses controversial medical interventions for longevity, highlighting the need for further research and scientific validation, as well as the potential risks and benefits associated with these interventions

Questions to inspire discussion 

• What are the potential risks and benefits of medical interventions for longevity?

  —The video discusses the potential risks and benefits of medical interventions for longevity, emphasizing the need for further research and scientific validation.

• What is the importance of consulting a physician for medical interventions?

  —The speaker, a PhD in genetics, emphasizes the importance of consulting a physician for medical interventions discussed in the series, and aims to distill scientific literature to help people determine what is best for their wellness.

• What is Inside Tracker and what does it offer?

• —Inside Tracker is a personalized nutrition platform that analyzes data from your blood and DNA to help you understand your body and reach your health goals, offering clear data presentation, actionable nutritional advice, and an inner age test to optimize your biological age.

• What are the potential side effects of testosterone replacement therapy (TRT)?

  —TRT has shown short-term improvements in libido and skeletal muscle mass, but it also has side effects such as sleep apnea, enlarged breasts, increased risk of estrogen conversion, benign prostatic hyperplasia, and shrinking testicles.

Key Insights 

Emerging Technologies in Longevity Research

• 🧬 "The idea that we can use stem cells to regenerate tissues and organs is still controversial, but I think it's going to be a big part of the future of medicine."
• 🤔 We only know about the detailed effects of 20 out of the thousand peptides made by the body, leaving a lot of potential for discovery in this area.
• 🧬 The discovery of over 100 genes encoded in the mitochondrial genome, including MOTS-C and humanin, challenges previous assumptions about the role of mitochondria in aging and longevity.
• 💊 The potential of exosomes to reverse senescence and rejuvenate cells is a remarkable and exciting avenue for longevity research.
• 🧠 "We have the ability in my lab to drive aging forwards in those what are called cerebral organoids and even in reverse." - Dr. David Sinclair discusses the ability to reverse aging in cerebral organoids, potentially leading to breakthroughs in studying the human brain without touching patients.
• 🔬 Cellular reprogramming may hold the key to reversing aging without negative side effects.
• 🐭 The nerves of the mice went back in time and their gene expression patterns were reset to being young again, resulting in the mice getting their vision back.
• 🧬 With the current pace of medical technologies, we could approach a time where every year you live, you get another year of life, making the world super interesting.

Medical Interventions and Longevity

• 🧬 The body has cycles of want and need, and adversity is good for long-term health, while abundance is great for short-term growth and reproduction.
• 💉 Peptides are becoming more accessible and popular for anti-aging purposes, with thousands of human studies showing their relative safety and effectiveness.
• 🧬 Exosome replacement can rejuvenate senescent cells, which can cause inflammation and even cancer, and deleting these cells is good for health.
• 🧬 Stem cells have the potential to make any type of cell in any type of tissue, making them a valuable tool for medical interventions for longevity.
• ⏳ If a person could truly reverse their age every year by one year, they would essentially stop aging.

Importance of Physician Consultation for Longevity Interventions

• 🩺 "The things we've talked about in this series should always be done with the supervision and advice from your physician." - it's important to consult with a physician before trying any medical interventions for longevity.

 #Health #Wellness

Clips

 00:00 📝 The podcast discusses controversial medical interventions for longevity, emphasizing the need for doctor supervision and acknowledging the lack of FDA approval for many of these interventions.

• • The podcast discusses controversial medical interventions for longevity, emphasizing the need for doctor supervision and acknowledging the lack of FDA approval for many of these interventions.
  • The speaker, a PhD in genetics, emphasizes the importance of consulting a physician for medical interventions discussed in the series, and aims to distill scientific literature to help people determine what is best for their wellness and what is not, covering topics such as stem cell therapy, peptides, exosomes, testosterone, growth hormone, and epigenetic reprogramming.
  • Athletic Greens is a daily drink that supports better health and peak performance, containing a blend of vitamins, minerals, and whole foods sourced ingredients, and offering a special offer of five free travel packs plus a year supply of vitamin D3 and vitamin K2.
  • Inside Tracker is a personalized nutrition platform that analyzes data from your blood and DNA to help you understand your body and reach your health goals, offering clear data presentation, actionable nutritional advice, and an inner age test to optimize your biological age.
  • Levels is an app that syncs with a continuous glucose monitor, allowing users to monitor their blood glucose levels and see how different foods impact them.
  • Testosterone replacement therapy (TRT) has become increasingly popular for both men and women due to the decline in testosterone levels with age, with benefits including sexual function, mental health, muscle building, fitness, and vitality, but it is important to note that feeling younger does not necessarily mean reversing biological aging.
• 06:36 💉 Testosterone replacement therapy (TRT) and human growth hormone (HGH) may provide short-term benefits for muscle growth and fat reduction, but long-term use may have negative effects on health and longevity, including increased risk of cancer, heart disease, and aging acceleration.
  • Testosterone replacement therapy signals the body that times are good and it's okay to build muscle, but while it may benefit in the short-term, it may not be great for long-term health and longevity.
  • TRT (testosterone replacement therapy) has shown short-term improvements in libido and skeletal muscle mass, but it also has side effects such as sleep apnea, enlarged breasts, increased risk of estrogen conversion, benign prostatic hyperplasia, and shrinking testicles.
  • Supplementing with testosterone may not lead to longer life and addressing the causes of biological aging is different from fixing current problems or improving quality of life.
  • Supplementing with human growth hormone may provide short-term benefits for things like muscle growth and fat reduction, but long-term use may have negative effects on health and longevity, as seen in studies on worms, mice, and humans with low levels of growth hormone.
  • Long-term use of HGH for longevity may increase the risk of cancer, heart disease, insulin resistance, joint pain, and type two diabetes, as it mimics abundance and accelerates aging.
  • Testosterone and growth hormone can be naturally increased through exercise and proper sleep, and supplementation should only be considered if natural methods are ineffective, with the focus on maintaining a healthy level rather than excessive increase; peptide supplementation is also popular.
• 14:09 🧪 Peptides, small strings of amino acids, have shown potential for increasing cellular communication and promoting regenerative signaling for anti-aging purposes, but more research is needed to determine their safety and effectiveness as the FDA is cautious about their limited knowledge and potential side effects.
  • Peptides are small strings of amino acids used by cells to communicate with each other, and while their specific functions are not fully understood, they have been shown to help increase cellular communication, which is beneficial for aging.
  • Insulin was discovered in 1921 and quickly used to cure diabetes in dogs and humans, leading to significant improvements in the lifespan of type one diabetics.
  • Peptides, which can be synthesized easily and cheaply, have been extensively studied and considered relatively safe for use in clinical settings due to their non-toxic nature and quick metabolism, with the goal of promoting regenerative signaling for anti-aging purposes.
  • MOTS-C, a peptide derived from mitochondrial DNA, has been shown to lower blood sugar levels, increase mitochondrial activity, and potentially promote longevity in mice and humans.
  • Peptides have the potential to address the causes of biological aging and show benefits such as reducing fat and improving fatty liver, but more research is needed to determine their safety and effectiveness, as the FDA is cautious due to their popularity and limited knowledge about them.
  • Peptides that have shown promising results for longevity interventions are now regulated by the FDA in the United States due to potential side effects, although some individuals still obtain them overseas.
• 20:56 🔬 Medical interventions like BP-157, SS-31, and GHK-Copper have potential benefits for blood flow, inflammation, regeneration, and more, but scientific validation is still needed; other interventions like Tesamorelin and CJC-1295 show promise for various conditions, but their effectiveness in humans is uncertain; placebo-controlled studies are necessary for TRT, HGH, and stem cells; exosomes may have diagnostic and lifespan-extending potential.
  • BP-157, SS-31, and GHK-Copper are popular medical interventions that can improve blood flow, lower inflammation, regenerate neurons, enhance mitochondrial function, promote wound healing, attract immune cells, stimulate collagen, protect tissues against inflammation, reduce fine lines and wrinkles, and promote hair growth.
  • Most of the information about the effects of medical interventions for longevity, such as peptides, is based on anecdotal evidence from mouse studies and current clinical studies, and while there is a movement to make these interventions more available, they are not yet scientifically validated.
  • Some medical interventions, such as Tesamorelin, CJC-1295, AOD-9604, BP-157, humanin, and Pinealon, have potential benefits for fighting infections, fat loss, diabetes, cardiovascular disease, neurodegenerative disease, memory, attention deficits, brain injury, stroke, and chronic fatigue.
  • These interventions, such as Dixhexa, Cerebrolysin, Semax, Selank, and BPC 157, are currently experimental and have shown effectiveness in mice, but it is still uncertain if they are effective in humans.
  • Placebo controlled, double blind clinical studies are necessary for medical interventions like TRT, HGH, and stem cells, which may have promising potential for treating aging and various conditions, but caution is needed to avoid negative side effects.
  • Exosomes, which are packages of information containing peptides, DNA, RNA, and micro RNAs, can be used for diagnosing diseases and potentially extending lifespan by simulating adversity.
• 27:12 🧪 Exosomes have shown potential in promoting longevity and reversing senescence, while stem cells can be reprogrammed to grow various tissues and study the human brain without touching patients.
  • Exosomes, when supplemented into mice, have shown potential in helping with injury and promoting longevity by communicating with the body and rejuvenating senescent cells.
  • Exosomes have the potential to reverse senescence and rejuvenate cells, offering a new avenue for therapy, although it is still in the early stages and considered experimental.
  • Exosomes, a scientifically validated pursuit, are being researched for their potential benefits in long-term health and longevity, but their safety and effectiveness over decades are still unknown.
  • Stem cells are cells that can divide to produce tissues, with two main types being multipotent cells that can make a few different types of tissues and pluripotent stem cells that can make any type of cell in any type of tissues.
  • By inducing a pluripotent stem cell state using Yamanaka factors, it is possible to reprogram adult cells into a state of pluripotency, allowing for the growth of various tissues and even the potential for cloning.
  • The speaker discusses their ability to study the human brain by driving aging forwards and in reverse using cerebral organoids, which allows for faster research without having to touch patients.
• 35:50 🧬 Stem cells can be used to treat areas of the body where cells are not functioning properly, but their effectiveness is limited by their inability to find their proper place; however, research is being done on reprogramming stem cells to reverse aging and improve overall health.
  • You can easily introduce these factors into a cell by passing electricity through the cells or using liposomes.
  • In the lab, adeno-associated viruses are used to package Yamanaka genes into cells, allowing them to be turned on and off with drugs, and while pluripotent cells can be used to treat areas of the body where cells are not functioning properly, there is a risk of cancer, which is why most stem cell therapies currently use harvested stem cells from various parts of the body, such as fat cells.
  • Stem cells age and undergo epigenetic changes that make them less able to regenerate new tissues, but they can be slowed down or replaced through new technologies such as capturing them at a younger state or using cord blood, which is becoming more common for people to preserve their child's ability to use those stem cells later on.
  • Parents should consider banking their children's cord blood as it has proven uses, especially in cases of childhood cancer, and there are companies and hospitals that can assist with the process.
  • Stem cells can be used to replace the immune system in older individuals and have potential implications for treating various diseases and aging.
  • Stem cells have the potential to rejuvenate the body and replace old cells, but their effectiveness is limited by their inability to find their proper place; however, research is being done on reprogramming stem cells to reverse aging and improve overall health.
• 46:50 🧬 Researchers are exploring the use of Yamanaka factors to restore eyesight and potentially reverse aging in mice and humans, while a triple treatment regimen has shown promise in reversing biological aging, but further research is needed to determine long-term effects.
  • The speaker discusses the use of Yamanaka factors to restore eyesight in mice by reintroducing the genes with a system that can turn them on at will using an antibiotic called doxycycline.
  • Reprogramming cells in the eye of mice has shown promising results in restoring vision, and researchers are hopeful that this mechanism can be applied to other tissues in the body, including humans, to potentially reverse the effects of aging and restore vision in patients with glaucoma or genetic diseases.
  • The genetic code remains the same, but the epigenetic code, which reads the DNA, can be reset to a more youthful state, although the process of how this occurs is still unknown, and researchers are exploring various methods such as cellular reprogramming, exosomes, and potentially developing a pill to reset the epigenetic clock.
  • A triple treatment regimen using growth hormone, DHEA, and Metformin has shown promising results in reversing biological aging in a small-scale trial.
  • Measuring the clock in the blood is just one indicator of rejuvenation, and it would be beneficial to measure aging in other tissues using different clocks to determine if the treatment is truly reversing aging or just some aspects of it, but the long-term effects are still unknown.
  • Repeated treatments over more than a year have shown promising results in reducing age based on the blood clock, indicating the potential for reversing aging, but further research is needed; however, there have been significant advancements in the ability to reprogram the body and measure biological age, and while waiting for these therapies to mature, individuals can slow down their biological clock by implementing lifestyle changes discussed in previous episodes, leading to a future where every year lived could potentially result in another year of life.
• 58:35 👍 Support the podcast by subscribing on YouTube, Apple podcasts, and Spotify, leaving a five-star review on Apple, checking out the sponsors, or supporting on Patreon.

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