Biotracking, Age Reversal & Other Advanced Health Technologies | Lifespan with Dr. David Sinclair #8

Advanced health technologies, such as wearable devices and genetic databases, have the potential to revolutionize healthcare by enabling early detection of diseases, personalized health tracking, and age reversal treatments, but concerns about data privacy and potential risks need to be addressed 

Questions to inspire discussion 

• What are some potential benefits of advanced health technologies?

  —Advanced health technologies have the potential to enable early disease detection, personalized health tracking, and age reversal treatments.

• How can wearables and implantables revolutionize healthcare?

  —Wearables and implantables can provide access to biological aging clocks and monitor various health markers, such as glucose levels and heart activity, leading to early detection of potential health issues.

• What is Levels and what does it monitor?

  —Levels is an app that syncs with a continuous glucose monitor to monitor blood glucose levels and its impact on health.

• What is InsideTracker and what does it offer?

  —InsideTracker is a personalized nutrition platform that provides blood and DNA analysis, including an inner age test, to help individuals understand their body and improve their health.

• How can advanced health technologies reduce diseases like cancer and heart attacks?

  —Advanced health technologies can provide early detection through devices that measure various biomarkers, including glucose levels, heart function, body fat percentage, and more, leading to a reduction in diseases like cancer and heart attacks.

Key Insights

Potential of Age Reversal and Longevity

• 💉 "And what we'll have is a massive reduction in diseases like all cancers, but colon cancer already. We're going to have heart attacks be a thing of the past pretty much, 'cause your doctor will know days in advance before you actually have a cardiac event."
• 📈 "And that's what I think will lengthen our lives by another decade, beyond what we're able to do with changes to lifestyle." - Dr. David Sinclair on the potential of advanced health technologies to extend human lifespan.
• 🧬 Dr. David Sinclair's research has found that certain lifestyle changes and supplements like NMN and Metformin can potentially lower biological age, offering the possibility of slowing down and even reversing aging.
• 🌟 The field of aging research is entering a golden age, with the potential for even greater advancements in age reversal, including reports of people going back 10 to 20 years with certain treatments.
• 🧪 "So we found that a combination of three of these genes and leaving out the other two dangerous ones, was a perfect way to reset the age of the body, without causing cancer."
• 🧬 "The retinal cells, the nerve cells that go to the brain, went back in time, they became young again, reset their age, according to the Horvath clock."
• ⏰ "There is a reset switch in the body, and that the clock is part of that system." - Dr. David Sinclair on the possibility of reversing aging.
• 💉 Greg Fahy's TRIIM Trial showed that a combination of Metformin, growth hormone, and DHEA can reset the epigenetic clock, reducing biological age by an average of two and a half years after just one year of treatment.
• 💉 "He's now getting people to go back five, and there are some reports of people going back 10 years in their blood's biological age." - Dr. David Sinclair discussing the potential effectiveness of age-reversal treatments.
• 🌍 The idea of humans living well past the 100 or 120 year mark may be difficult for many to comprehend, but it raises the possibility of a future where people live significantly longer and healthier lives.

Advancements in Health Monitoring Technology

• 📈 The ability to measure and track biological aging clocks through wearables and implantables will revolutionize how we approach healthcare and improve overall health outcomes.
• 📊 Monitoring blood glucose levels and understanding how different foods impact them is crucial for daily energy and long-term health.
• 💉 With advanced biotracking technologies, it is now possible to detect 50 different types of cancers at their earliest stages, years before they would show up and have you go to a doctor, potentially saving lives.
• 🩸 Continuous glucose monitors, like the Levels monitor, provide active monitoring of blood glucose levels, offering valuable insights for individuals managing their health.
• 🤔 Wearing a blood sugar tracking device has provided me with more knowledge about blood sugar in a week than I had in my entire life before, highlighting the importance of monitoring blood sugar levels even for individuals who are not diabetic or prediabetic.

Shifts in Healthcare Paradigm

• ⏳ The traditional healthcare model of waiting until you get sick to see a doctor is outdated, as technology now allows for remote monitoring and testing, providing doctors with more information than ever before.
• 🕰️ The longer we live, the longer we will live, as advancements in technology and monitoring allow us to extend our lifespan.

 #Health #Wellness

Clips 

• 00:00 📈 Blood tests can be done remotely, wearables and implantables will revolutionize healthcare, and early detection tests for cancer and cardiovascular disease can greatly improve health outcomes.
  • The podcast discusses the rapid advancements in health technologies and the potential for greatly extending our lifespans, including the shift towards telemedicine and self-administered healthcare.
  • Blood tests can be done remotely in the future, reducing the need to visit a doctor's office, and monitoring at home can prevent infections acquired in hospitals, while wearables and implantables will revolutionize healthcare by providing access to biological aging clocks.
  • Levels is an app that syncs with a continuous glucose monitor to monitor blood glucose levels and its impact on health, while Athletic Greens is an all-in-one daily greens drink that supports better health and peak performance.
  • InsideTracker is a personalized nutrition platform that provides blood and DNA analysis, including an inner age test, to help individuals understand their body and improve their health, offering convenience and more information than traditional in-person doctor visits.
  • The speaker discusses the outdated model of medicine in the 20th century where doctors only test for diseases when symptoms are present, leading to late detection and potential death.
  • Tests that can detect 50 types of cancers at early stages by analyzing blood signals, such as DNA fragments, can significantly reduce cancer incidence and death rates, and similar tests can also predict cardiovascular disease.
• 11:30 📱 A BioButton device, similar to Iron Man, is being used to monitor the body in real-time, including heart activity, to detect potential health issues early and save costs for hospitals.
  • The speaker wears a BioButton device, similar to Iron Man, on his chest.
  • A device is being used to monitor the body in real-time, including heart activity, to detect potential health issues early and save costs for hospitals.
  • Monitoring blood sugar levels and understanding how different foods affect them can fundamentally change the way we think about our diet and its impact on our health.
  • People should have the right to look inside their bodies and interpret the data, and wearables like blood glucose monitors have come a long way in providing accessible and continuous measurements.
  • You can now use your genetic profile and biomarkers to determine your risk for disease and consult with a doctor to monitor specific health markers, as the current medical system is not designed to provide tests for preventative purposes.
  • Most people's insurance doesn't cover advanced health technologies unless they reach a certain threshold, but countries like Australia provide free colon cancer tests and sunblock on beaches, which saves money in the long run.
• 18:49 📊 Having a dashboard for our bodies, similar to a car dashboard, is necessary for understanding and monitoring our health, and advanced health technologies can help reduce diseases by providing early detection through devices that measure various biomarkers; however, there are concerns about data ownership, storage, and privacy regulations that need to be addressed before giving away personal health data.
  • Doctors are supportive of individuals measuring their own health data and believe that having a dashboard for our bodies, similar to a car dashboard, is necessary for understanding and monitoring our health.
  • Advanced health technologies can help reduce diseases like cancer and heart attacks by providing early detection through devices that measure various biomarkers, including glucose, heart function, body fat percentage, muscle mass, ECGs, caloric intake, temperature, UV exposure, sleep quality, and blood oxygen.
  • CRP, glucose, TNF alpha, IL one, six, cortisol, lactate, and blood oxygen levels are important markers for predicting cardiovascular disease, inflammation, stress levels, exercise performance, and overall longevity.
  • In the future, there will be wearable and implantable biosensors that can measure various health markers, and it is important for everyone to have a biosensor to monitor their health and utilize AI to process the data effectively.
  • The concern is that personal health data will need to be uploaded to a company's cloud, and while there are many companies developing these technologies, there are concerns about data ownership, storage, and privacy regulations that need to be addressed before giving away this massive amount of data.
  • We need to start a conversation about including regulations for advanced health technologies, as it is a rapidly approaching reality that should not be delayed by waiting for laws to catch up with the technology.
• 26:37 🔬 Genetic databases can be used to solve cold cases, highlighting the potential dangers of releasing genetic data, and the importance of protecting health data; Arc Bio has developed a technology to detect infectious diseases in human blood; various health sensors are discussed, including blood glucose monitors and tooth sensors; trade-offs in advanced health technologies need to be considered.
  • When individuals consent to release their genetic data, they are not only making a personal choice but also making a choice for their family, as demonstrated by the use of genetic databases to solve cold cases, which highlights the potential dangers of this technology in the wrong hands.
  • The importance of ensuring tight laws to protect health data from being used for nefarious purposes and the potential implications of tracking infectious diseases on privacy and collective good are discussed.
  • Arc Bio has developed a technology that can detect viruses, fungi, and bacteria in human blood, allowing for the diagnosis of infectious diseases without prior knowledge of what to look for, which has implications for the future of healthcare and the internet of things.
  • The speaker discusses various health sensors they currently use and are excited about, including a blood glucose monitor, a sleep and heart rate ring, a heart and movement watch, and upcoming technologies they are blind to.
  • There are advanced health technologies such as contact lenses for measuring blood glucose levels, tooth sensors for measuring bacteria in the mouth, and a colon cancer test that analyzes gut health through a poop sample, which can be sent by mail or potentially monitored through a device in the home.
  • There are trade-offs in advanced health technologies, such as potential embarrassment and privacy implications, that need to be weighed against the potential benefits.
• 33:14 📊 Biosensors and advanced health technologies will allow constant monitoring of individuals to detect potential health issues, measure biological age, receive personalized nutritional recommendations, and optimize health through tailored treatments and exercise.
  • Biosensors, such as mouth guards and temporary tattoos, can detect markers in the blood and saliva, and the future of health monitoring will involve constant monitoring of individuals of all ages to detect potential health issues and extend lifespan.
  • There are ways to measure biological age, and efforts are being made to make it cheaper and faster, so people can routinely measure their biological age at home and make informed decisions about slowing down and reversing aging.
  • In the future, advanced health technologies will allow us to use apps to track our biological measurements, receive nutritional recommendations, and make informed decisions about our diet and lifestyle to optimize our health.
  • Supplementation, particularly for those on specialized diets, may be necessary to optimize nutrient levels, and in the future, there may be machines in our homes that can create personalized pills with minerals, vitamins, and medicines.
  • Medicine is currently based on averages and doesn't take into account individual factors such as genetics, history, and biological age, but with personalized pills and AI assistance, doctors will be able to provide more tailored treatments in the future.
  • Tracking devices and measurements can help us exercise more effectively, bringing down individual levels and potentially reducing our biological age over time.
• 42:30 🔬 Personalized health tracking and guidance will replace annual physicals, with customized exercise, diet, and supplementation plans based on genetic and physical makeup, while age reversal treatments and gene therapy show promising results in mice and human organoids for potential treatment of diseases of old age.
  • In the future, personalized health tracking and guidance will replace annual physicals, as individuals will have customized exercise, diet, and supplementation plans based on their unique genetic and physical makeup.
  • Supplements and drugs like NMN can provide benefits, but exercise is still crucial for optimal health and longevity.
  • Age reversal treatments, currently being tested on mice and patients in California, have shown promising results with a couple of years retreat in age in just 12 months of treatment, and there is potential for even greater age reversal in the future.
  • Scientists have discovered a gene therapy that can reverse the biological age of mice by activating three specific genes, which are part of the Yamanaka factors, without causing cancer.
  • By using a virus to insert three specific genes into the eyes of mice, researchers were able to reverse the effects of optic nerve damage and glaucoma, restoring the mice's vision and resetting their gene expression patterns, indicating a potential cure for blindness in humans.
  • Aging reversal through gene therapy and resetting the age of the body is being researched and has shown promising results in mice and human organoids, with the potential to treat diseases of old age such as Alzheimer's and cancer in the future.
• 52:08 🧬 Greg Fahy's TRIIM Trial successfully reversed biological aging by an average of 2.5 years using a combination of Metformin, growth hormone, and DHEA, with potential to reset biological age by up to 10 years, but there are potential dangers such as stimulating cancer cells; gene therapy is not recommended due to irreversible risks and side effects, but advances in virus distribution could extend lifespan; extending lifespan and improving human biology will not lead to overpopulation.
  • Greg Fahy's TRIIM Trial used a combination of Metformin, growth hormone, and DHEA to reset the epigenetic clock and reverse biological aging by an average of two and a half years after one year of treatment.
  • Repeated treatments have shown the potential to reset biological age, with reports of people reversing their blood's biological age by up to 10 years.
  • Resetting the age may have potential dangers such as stimulating cancer cells, but the speaker is optimistic that if the body becomes younger, it will be able to surveil and kill those cancer cells.
  • Gene therapy is not recommended due to potential irreversible risks and side effects, including immune responses to viruses used in the therapy.
  • Advances in distributing viruses evenly throughout the body could potentially extend the lifespan of mice and eventually lead to humans living much longer, healthier lives.
  • Extending lifespan and improving human biology will not lead to overpopulation, as population growth rates are declining and advancements in healthcare will make people more productive and less costly to the economy.
• 58:55 🔬 Investing in advanced health technologies can improve lives and address global issues, but it's important to use the money wisely; lengthening lifespans and promoting healthy aging can lead to more productive years and reduce wasted potential; take responsibility for your health through proper nutrition, fasting, exercise, and exposure to adversity; supplements and new technologies can extend lifespan; support the show and provide feedback at patreon.com/davidsinclair.
  • The significant amount of money being invested in advanced health technologies can be used to address other global issues and improve people's lives, but it is crucial to ensure that it is used wisely and for the right purposes.
  • Lengthening lifespans and promoting healthy aging would allow for more productive years, providing opportunities for career changes and the ability to contribute wisdom and knowledge to society, ultimately reducing the waste of potential when individuals die at older ages.
  • Take responsibility for your health and longevity by eating the right way, fasting, exercising, and exposing your body to adversity mimetics like cold and heat.
  • The speaker discusses supplements and new technologies that can extend lifespan, explaining that as these technologies advance, each year lived will result in even more additional years of life.
  • The speaker concludes the video by thanking viewers for their support, encouraging them to provide feedback and suggestions for future episodes, and promoting ways to support the show through sharing and subscribing.

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