Improving Gut Health with Microbiome and Probiotics

The microbiome is a mutable and important factor in gut health, and interventions such as diet, probiotics, and potential new antibiotics from animal microbiomes can have significant impacts on overall health and specific conditions like type 2 diabetes and bipolar disorder

𝑸𝙪𝒆𝙨𝒕𝙞𝒐𝙣𝒔 𝒕𝙤 𝙞𝒏𝙨𝒑𝙞𝒓𝙚 𝙙𝒊𝙨𝒄𝙪𝒔𝙨𝒊𝙤𝒏

• What is the microbiome?

  —The microbiome consists of all the microbes residing in and on the body, and it can be developed to improve health through microbiome intervention.

• How does diet influence the microbiome?

  —Diet is a significant factor in the variation of people's microbiomes at the strain level, and consuming probiotics and prebiotics can improve GI symptoms.

• What impact do antibiotics have on the gut microbiome?

  —Antibiotics can disrupt the gut microbiome, leading to overgrowth of harmful bacteria, but fecal microbiome transplants have a high success rate in treating infections.

• How can probiotics be more effective?

  —Probiotic effectiveness is not solely determined by the number of colony forming units, and the process of freeze-drying probiotics is essential for maintaining their viability and stability.

• What are ongoing studies focused on?

  —Ongoing studies are being conducted to replicate the results of a study on the effects of a supplement on type 2 diabetes, and clinical trials for microbiome interventions are being conducted around the world.

𝑲𝙚𝒚 𝑰𝙣𝒔𝙞𝒈𝙝𝒕𝙨

• 🐶 "It's a function of what they're eating is such a big driving Factor so if you look at your pet dog."
• 🌱 The microbiome is uniquely positioned to metabolize fibers, which are essential for gut health and the production of important short chain fatty acids.
• 🥣 Probiotics in yogurt can improve GI symptoms, but it's important to watch out for added sugars.
• 📊 Higher levels of acromania in the microbiome are correlated with better responses to dietary interventions, suggesting the importance of individual microbiome composition.
• 🦠 The reorganization of the gut microbiome through gastric bypass surgery can lead to immediate improvements in glycemic control, even before weight loss occurs.

#Health #Wellness #GutHealth #Microbiome

𝐂𝐥𝐢𝐩𝐬

• 00:00 🦠 The microbiome is mutable and can be developed to improve health through intervention, with diet playing a significant role, and the potential for new antibiotics from animal microbiomes.
  • The microbiome is mutable and can be developed to improve health through microbiome intervention, with the potential for manufacturing products with efficacy, and the microbiome consists of all the microbes residing in and on the body.
  • The gut microbiome is initially seeded through delivery in the vaginal canal, peaks in diversity at a relatively young age, and is made up of a huge portion of the body's mass and functions.
  • Bacterial cells are their own living organisms that can replicate and evolve rapidly, and while some bacteria can be harmful, most have a mutually beneficial relationship with their host.
  • Cherium defil is present in most people's guts but its impact depends on the context of the ecosystem, and the human microbiome project found that people's microbiomes vary greatly at the strain level, with diet being a significant factor.
  • The microbiome is complex and influenced by diet, with unknown roles and implications of viruses, and animal models may not accurately predict human microbiome responses.
  • Gut health and the microbiome are studied using germ-free mouse models, with bacteria in the gut being strictly anaerobic and changing along the length of the digestive tract, with potential for new antibiotics from the microbiome of animals like hyenas.
• 22:42 🦠 The microbiome is constantly evolving and can be measured through sequencing methods to understand its impact on gut health and drug metabolism.
  • The microbiome consists of different bacteria strains that can be classified based on their genomic makeup and function, and it is important to monitor and audit these strains to ensure their function is not impacted by genetic modifications.
  • The rapid evolution of gut bacteria is driven by their optimization for the environment, including the food we feed them, leading to constant changes in the gut biome.
  • The microbiome is mutable and can be measured through shotgun sequencing, which involves both short read and long read sequencing to accurately capture the genetic information of different microbes.
  • The microbiome and gut health can impact the metabolism and efficacy of certain drugs, and studying the microbiome involves sequencing and qpcr-based methods to understand the presence and impact of different bacterial strains.
  • Understanding and maintaining the microbiome requires quantitative PCR to measure the presence of specific strains, longitudinal data to track changes, and functional assays to assess the output of carbohydrate metabolism.
  • Sampling the microbiome from the distal and proximal ends of the gut can be challenging due to potential contamination, but it could potentially be done operatively.
• 39:52 🦠 The gut microbiome is essential for gut health and can be disrupted by antibiotics, leading to potential health issues, but fecal microbiome transplants show promise in treating infections despite associated risks and uncertainties.
  • The microbiome metabolizes insoluble fiber into short chain fatty acids, particularly butyrate, which is essential for gut health and can be obtained from external sources or supplements.
  • The gut microbiome can be disrupted by antibiotics, leading to overgrowth of harmful bacteria, but fecal microbiome transplants have a high success rate in treating infections, although there are still risks and uncertainties associated with the procedure.
  • Antibiotics can affect gut bacteria, leading to changes in food cravings and neurotransmitter production, potentially influencing obesity and mental health.
  • Factors such as antibiotics, nutrition, aging, stress, disrupted circadian rhythm, and menopause can deplete the microbiome, affecting the gut and vaginal microbiome, potentially leading to various health issues.
  • The evidence from studies in mice suggests that fecal microbiome transplants can change metabolism, but challenges in safety, reproducibility, and identifying specific beneficial components make it difficult to translate these findings to humans.
  • Microbiome science has been around since the 70s, with new strains requiring FDA approval, and pharmaceutical companies are using the microbiome for therapeutic purposes.
• 01:10:53 🦠 Gut health is influenced by diet and the host, probiotics can improve GI symptoms but effectiveness depends on encapsulation and freeze-drying process, and it's important to focus on the specific problem and avoid marketing hype.
  • Acromania has become an interesting strain in studying the microbiome, with research showing that metabolically healthy individuals have 5-10% of this strain regardless of diet, while those with metabolic syndrome have a depletion of it.
  • The microbiome is influenced by diet and the host, and consuming probiotics and prebiotics can improve GI symptoms, but it's important to be mindful of added sugars in yogurt.
  • Probiotic effectiveness is not solely determined by the number of colony forming units, as flow cytometry can provide a more accurate assessment of live, dead, and in-between cells, and the freeze-drying process can result in a significant loss of live bacteria.
  • The process of freeze-drying probiotics is essential for maintaining their viability and stability, but even after this process, they may still need to be refrigerated, and only a portion of the probiotics will make it to the gut microbiome.
  • The effectiveness of probiotics depends on the encapsulation used, with lactobacillus and bifido bacterium strains producing lactic acid and short chain fatty acids, but the accuracy of CFU labeling and the need for government regulation is uncertain.
  • Focus on the minimum viable product to solve the specific problem you are trying to address, rather than getting caught up in marketing hype and taking supplements without understanding their purpose.
• 01:31:03 🦠 Taking antibiotics can disrupt the gut microbiome, so it's important to consider probiotics and a high fiber diet for reconstitution, while non-nutritive sweeteners may have conflicting effects on the microbiome.
  • Taking antibiotics can have a significant impact on the gut microbiome, and it is important to consider probiotics and a high fiber diet to help reconstitute a healthy microbiome after antibiotic use.
  • Antibiotics can decimate the gut microbiome, so it's important to eat a high-fiber, high-polyphenol diet and avoid high-fat, high-sugar foods during recolonization.
  • Non-nutritive sweeteners have a potential impact on the microbiome, but the data is conflicting and more research is needed to understand their effects.
  • Consuming non-nutritive sweeteners like aspartame can have different effects on individuals based on their microbiome, and studies should use crossover designs to better understand these effects.
  • Acromania is a strict anaerobe that is difficult to grow and maintain, leading to many fake products claiming to contain it.
  • The process of growing and maintaining a stable microbiome strain involves creating a no oxygen environment, pumping in multiple gases, freeze drying the strain, and keeping moisture out to prevent oxygen from entering.
• 01:55:53 🔬 Bringing microbiome products directly to consumers is the best approach, as acromania stimulates glp1 production and impacts metabolism, with potential benefits for glycemic control in type two diabetes.
  • The speaker discusses the process of manufacturing probiotics and the use of anerobic chambers for flow cytometry.
  • The company has invested heavily in research and development to bring a microbiome product to market, believing that bringing it directly to consumers is the best approach, despite the challenges of marketing in the industry.
  • Acromania stimulates the production of glp1, which helps lower blood glucose, reduce food cravings, and impact body weight.
  • Acromania plays a role in impacting metabolism and blood sugar, and its effects on the microbiome are more physiologically relevant than injecting gp1s straight into the bloodstream.
  • Gut reorganization through gastric bypass surgery can lead to immediate improvements in glycemic control, potentially due to changes in the gut microbiome, but the specific mechanisms are not fully understood.
  • The speaker discusses the results of a clinical trial involving a five-strain formulation, including acromania, which showed significant improvements in A1C and blood glucose levels in people with type two diabetes.
• 02:21:46 🔬 Ongoing studies on microbiome interventions for type 2 diabetes and bipolar disorder, including the effectiveness of a supplement, the development of new probiotic products, and the importance of nutrition information for customers.
  • Ongoing studies are being conducted to replicate the results of a study on the effects of a supplement on type 2 diabetes, and investors are supportive of the need for clinical trials to validate the product's effectiveness.
  • Clinical trials for microbiome interventions, specifically for type two diabetes and bipolar disorder, are being conducted around the world, with a focus on the efficacy of the product "glucose control" and the importance of offering nutrition information to customers.
  • Probiotics are expensive to produce and ship, so the company created a lower dose version at a more affordable price point, as well as single strain products that have been successful in the market.
  • People experienced a significant reduction in food cravings after taking a product for 90 days, leading to a pilot study and the collection of stool samples to analyze the gut biome.
  • The study showed that the encapsulated strains were delivered successfully, with most participants showing an increase in strains during the 90-day period, and a small percentage maintaining their levels even after the washout period, prompting the idea of delivering high fiber meals to test its impact on the microbiome.
  • The speaker discusses the impact of microbiome on health, the development of new products, and the need for more research on dosing and colonization.
• 02:47:49 🦠 There are promising strains of probiotics beyond acromania that may be available in the future, particularly those that impact the immune response.

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